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Generation of functional hemangioblasts from human embryonic stem cells

Shi-Jiang Lu, Qiang Feng, Sergio Caballero, Yu Chen, Malcolm A S Moore, Maria B Grant & Robert Lanza

Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all hematopoietic cell lineages. Here we describe an efficient and reproducible method for generating large numbers of these bipotential progenitors—known as hemangioblasts—from human embryonic stem (hES) cells using an in vitro differentiation system. Blast cells expressed gene signatures characteristic of hemangioblasts, and could be expanded, cryopreserved and differentiated into multiple hematopoietic lineages as well as into endothelial cells. When we injected these cells into rats with diabetes or into mice with ischemia-reperfusion injury of the retina, they localized to the site of injury in the damaged vasculature and appeared to participate in repair. Injection of the cells also reduced the mortality rate after myocardial infarction and restored blood flow in hind limb ischemia in mouse models. Our data suggest that hES-derived blast cells (hES-BCs) could be important in vascular repair.

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Robert Lanza takes the Ice Bucket Challenge

Robert Lanza Article Thumbnail Graphic

"Before I did the #icebucketchallenge, I challenged the leader of Advanced Cell Technology (ACT), Dr. Bob Lanza, to do the Ice Bucket Challenge. He did it and leading up to it he provided a quite articulate message for context (see video). Bob is one very cool guy even without ice water."
Paul Knoepfler

Entire Company takes the Ice Bucket Challenge. Click Here to See Video.